Patch testing to a textile dye mix by the international contact dermatitis research group.

Abstract

BACKGROUND:

Disperse dyes are well-known contact sensitizers not included in the majority of commercially available baseline series.

OBJECTIVE:

To investigate the outcome of patch testing to a textile dye mix (TDM) consisting of 8 disperse dyes.

METHODS:

Two thousand four hundred ninety-three consecutive dermatitis patients in 9 dermatology clinics were patch tested with a TDM 6.6%, consisting of Disperse (D) Blue 35, D Yellow 3, D Orange 1 and 3, D Red 1 and 17, all 1.0% each, and D Blue 106 and D Blue 124, each 0.3%. 90 reacted positively to the TDM. About 92.2% of the patients allergic to the TDM were also tested with the 8 separate dyes.

RESULTS:

Contact allergy to TDM was found in 3.6% (1.3-18.2) Simultaneous reactivity to p-phenylenediamine was found in 61.1% of the TDM-positive patients. Contact allergy to TDM and not to other p-amino-substituted sensitizers was diagnosed in 1.2%. The most frequent dye allergen in the TDM-positive patients was D Orange 3.

CONCLUSIONS:

Over 30% of the TDM allergic patients had been missed if only the international baseline series was tested. Contact allergy to TDM could explain or contribute to dermatitis in over 20% of the patients. Textile dye mix should be considered for inclusion into the international baseline series.

• Authors: Marléne Isaksson, Iris Ale, Klaus E Andersen, Thomas Diepgen, Chee-Leok Goh, An Goossens R, Hemangi Jerajani, Howard I Maibach, Denis Sasseville, Magnus Bruze
• Journal: Dermatitis : contact, atopic, occupational, drug (Dermatitis) 2015 Jul-Aug Vol. 26 Issue 4 Pg. 170-6 ISSN: 2162-5220 [Electronic] United States
• PMID: 26172486 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anthraquinones
• Azo Compounds
• Coloring Agents
• Phenylenediamines
• Dispersion Yellow 3
• disperse blue 35
• Disperse Orange 1
• Disperse Red 1
• Disperse Blue 124
• Disperse Orange 3
• disperse blue 106
• 4-phenylenediamine

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Anthraquinones (adverse effects)
• Azo Compounds (adverse effects)
• Child
• Coloring Agents (adverse effects)
• Dermatitis, Allergic Contact (diagnosis, etiology)
• Female
• Humans
• Male
• Middle Aged
• Patch Tests
• Phenylenediamines (adverse effects)
• Textiles
• Young Adult