Comparative evaluation of HMG CoA reductase inhibitors in experimentally-induced myocardial necrosis: Biochemical, morphological and histological studies.

Abstract

The present study was carried out to evaluate the protective effect of different statins on isoproterenol (ISO) induced myocardial necrosis. Atorvastatin, rosuvastatin, fluvastatin, simvastatin and pravastatin (10 mg/kg/day) were administered for 12 weeks. After pretreatment of 12 weeks myocardial necrosis was induced by subsequent injection of ISO (85 mg/kg/day, s.c.) to wistar rats. Serum biochemical parameters like glucose, lipid profile, cardiac markers and transaminases were evaluated. Animals were killed and heart was excised for histopathology and antioxidant study. Statins pretreated rats showed significant protection against ISO induced elevation in serum biochemical parameters and serum level of cardiac marker enzymes and transaminase level as compared to ISO control group. Mild to moderate protection was observed in different statins treated heart in histopathology and TTC stained sections. Result from our study also revealed that statins could efficiently protect against ISO intoxicated myocardial necrosis by impairing membrane bound enzyme integrity and endogenous antioxidant enzyme levels. Amongst all statins used, rosuvastatin and pravastatin were found to have maximum cardio-protective activity against ISO induced myocardial necrosis as compared to other statins.

• Authors: Bhavesh C Variya, Snehal S Patel, Jinal I Trivedi, Hardik P Gandhi, S P Rathod
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 764 Pg. 283-291 (Oct 05 2015) ISSN: 1879-0712 [Electronic] Netherlands
• PMID: 26169562 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier B.V. All rights reserved.

Chemical References

• Blood Glucose
• Cardiotonic Agents
• Fatty Acids, Monounsaturated
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Indoles
• Triglycerides
• Fluvastatin
• Rosuvastatin Calcium
• Cholesterol
• Atorvastatin
• Simvastatin
• Catalase
• Superoxide Dismutase
• Adenosine Triphosphatases
• Glutathione
• Pravastatin
• Isoproterenol

Topics

• Adenosine Triphosphatases (metabolism)
• Animals
• Atorvastatin (pharmacology, therapeutic use)
• Blood Glucose (analysis)
• Cardiotonic Agents (pharmacology, therapeutic use)
• Catalase (metabolism)
• Cholesterol (blood)
• Fatty Acids, Monounsaturated (pharmacology, therapeutic use)
• Fluvastatin
• Glutathione (metabolism)
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (pharmacology, therapeutic use)
• Indoles (pharmacology, therapeutic use)
• Isoproterenol (pharmacology, therapeutic use)
• Male
• Myocardial Infarction (chemically induced, drug therapy, metabolism, pathology)
• Myocardium (metabolism, pathology)
• Necrosis (chemically induced, drug therapy, metabolism, pathology)
• Pravastatin (pharmacology, therapeutic use)
• Rats, Wistar
• Rosuvastatin Calcium (pharmacology, therapeutic use)
• Simvastatin (pharmacology, therapeutic use)
• Superoxide Dismutase (metabolism)
• Triglycerides (blood)