Abstract | PURPOSE: METHODS: We collected data on risk factors, body size, and blood pressure via in-person interviews and examinations and measured glucose, triglycerides, and HDL-C from dried blood spots from women recruited through a mammography screening clinic (n = 373; 68 % Hispanic, 17 % African-American, 63 % foreign born). We performed linear regression models to examine the associations of each MetS component and the MetS cluster (≥3 components) with percent density and dense breast area, measured using a computer-assisted technique and Cumulus software. RESULTS: About 45 % of women had the MetS, with the prevalence of the individual components ranging from 68 % for abdominal obesity to 33 % for elevated triglycerides. The prevalence of the MetS increased with higher body mass index (BMI) and postmenopausal status, but did not vary substantially by ethnicity, immigrant generational status, parity, age at menarche, or alcohol consumption. Low HDL-C (<50 mg/dL), but not the MetS cluster or the other MetS components, was associated with larger dense breast area after adjusting for age, BMI, fasting time, and educational attainment (β = 8.77, 95 % CI 2.39, 15.14). The MetS and its individual components were not associated with BMI-adjusted percent density. CONCLUSIONS: HDL-C alone may have an influence on dense breast tissue that is independent of BMI, and may be in the same direction as its association with breast cancer risk.
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Authors | Parisa Tehranifar, Angeline Protacio, Karen M Schmitt, Elise Desperito, Sabine Oskar, Alan J Potter, Natalie J Engmann, Mary Beth Terry |
Journal | Cancer causes & control : CCC
(Cancer Causes Control)
Vol. 26
Issue 10
Pg. 1393-403
(Oct 2015)
ISSN: 1573-7225 [Electronic] Netherlands |
PMID | 26169301
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Cholesterol, HDL
- Triglycerides
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Topics |
- Black or African American
- Blood Glucose
(metabolism)
- Blood Pressure
- Body Mass Index
- Breast
(anatomy & histology)
- Breast Neoplasms
(complications)
- Cholesterol, HDL
(blood)
- Emigrants and Immigrants
- Female
- Hispanic or Latino
- Humans
- Hypertension
(complications)
- Mammography
- Metabolic Syndrome
(blood, diagnostic imaging, ethnology)
- Middle Aged
- Obesity, Abdominal
(complications)
- Prevalence
- Risk Factors
- Triglycerides
(blood)
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