Favorable survival after allogeneic stem cell transplantation with reduced-intensity conditioning regimens for relapsed/refractory follicular lymphoma.
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| Abstract |
Allogeneic stem cell transplantation (allo-SCT) is a curative option for patients with relapsed follicular lymphoma (FL). Prospective studies of reduced-intensity conditioning (RIC) have revealed that chemosensitivity at allo-SCT is the most reliable predictor of outcome; however, limited data are available for progressive/refractory disease. We report here a retrospective analysis of RIC allo-SCT for patients with FL. The purpose of this study was to elucidate the role of allo-SCT for patients with relapsed/refractory FL. We analyzed 46 patients-11 (24%) transplanted in CR, 6 (13%) transplanted in PR and 29 (63%) with progressive/refractory disease. The estimated 5-year overall survival rate was 71.6% (95% confidence interval (CI), 51.5-84.5%). According to the disease status at transplantation, the 5-year survival rate was 80.7% (95% CI, 37.7-95.4%) in the patients with CR or PR and 66.1% (95% CI, 41.5-82.3%) in those with progressive/refractory disease (P=0.29). There were no differences in relapse/progression and non-relapse mortality between the patients with chemosensitive disease and progressive/refractory disease. Allo-SCT may be a valuable treatment option, even for patients with progressive/refractory FL.
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| Authors | S Yano, T Mori, Y Kanda, J Kato, C Nakaseko, S Fujisawa, N Tomita, R Sakai, K Shono, T Saitoh, N Aotsuka, N Kobayashi, T Saito, S Takahashi, H Kanamori, S Okamoto, Kanto Study Group for Cell Therapy (KSGCT) |
| Journal | Bone marrow transplantation (Bone Marrow Transplant) Vol. 50 Issue 10 Pg. 1299-305 (Oct 2015) ISSN: 1476-5365 [Electronic] England |
| PMID | 26168068 (Publication Type: Journal Article) |
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