Abstract | PURPOSE: METHODS: A total of 73 brain lesions ( glioma: 31, brain metastasis: 42) in 70 patients who underwent MET-PET were included in this study. Visual analysis was performed by comparison of MET uptake in the brain lesion with MET uptake in one of four regions (around the lesion, contralateral frontal lobe, contralateral area, and contralateral cerebellar cortex). The concordance rate and logistic regression analysis were used to evaluate the diagnostic ability of visual assessment. Receiver-operating characteristic curve analysis was used to compare visual assessment with quantitative assessment based on the lesion-to-normal (L/N) ratio of MET uptake. RESULTS: Interobserver and intraobserver κ-values were highest at 0.657 and 0.714, respectively, when assessing MET uptake in the lesion compared to that in the contralateral cerebellar cortex. Logistic regression analysis showed that assessing MET uptake in the contralateral cerebellar cortex with brain metastasis was significantly related to the final result. The highest area under the receiver-operating characteristic curve (AUC) with visual assessment for brain metastasis was 0.85, showing no statistically significant difference with L/Nmax of the contralateral brain (AUC = 0.89) or with L/Nmean of the contralateral cerebellar cortex (AUC = 0.89), which were the areas that were the highest in the quantitative assessment. For evaluation of gliomas, no specific candidate was confirmed among the four areas used in visual assessment, and no significant difference was seen between visual assessment and quantitative assessment. CONCLUSION: The visual assessment showed no significant difference from quantitative assessment of MET-PET with a relevant cut-off value for the differentiation of recurrent brain tumors from radiation-induced necrosis.
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Authors | Ryogo Minamimoto, Toshiyuki Saginoya, Chisato Kondo, Noriaki Tomura, Kimiteru Ito, Yuka Matsuo, Shigeo Matsunaga, Takashi Shuto, Atsuya Akabane, Yoko Miyata, Shuji Sakai, Kazuo Kubota |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 7
Pg. e0132515
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 26167681
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carbon Radioisotopes
- Methionine
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Brain
(diagnostic imaging, pathology)
- Brain Neoplasms
(diagnostic imaging, pathology, radiotherapy)
- Carbon Radioisotopes
(metabolism)
- Diagnosis, Differential
- Female
- Glioma
(diagnostic imaging, pathology, radiotherapy)
- Humans
- Male
- Methionine
(metabolism)
- Middle Aged
- Necrosis
- Neoplasm Recurrence, Local
(diagnostic imaging)
- Neuroimaging
- Observer Variation
- Positron-Emission Tomography
(methods)
- Retrospective Studies
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