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Oleuropein-Rich Diet Attenuates Hyperglycemia and Impaired Glucose Tolerance in Type 2 Diabetes Model Mouse.

Abstract
Oleuropein, a phenolic compound found in abundance in olive leaves, has beneficial effects on various diseases. However, it is unknown whether an oleuropein-rich diet is efficacious against type 2 diabetic phenotypes. In this study, we investigated the effects of the oleuropein-containing supplement OPIACE, whose oleuropein content exceeds 35% (w/w), on the diabetic phenotypes in type 2 diabetes model Tsumura Suzuki Obese Diabetes (TSOD) mouse. TSOD mice were fed OPIACE at 4 weeks of age, i.e., before the TSOD mice exhibited diabetic phenotypes. We revealed that OPIACE attenuated hyperglycemia and impaired glucose tolerance in TSOD mice over the long-term (from 10 to 24 weeks of age) but had no effect on obesity. Furthermore, we demonstrated that OPIACE mildly reduced oxidative stress in TSOD mice by 26.2% and attenuated anxiety-like behavioral abnormality in aged TSOD mice. The results suggest that oleuropein suppresses the progression of type 2 diabetes and diabetes-related behavioral abnormality over the long-term.
AuthorsKazutoshi Murotomi, Aya Umeno, Mayu Yasunaga, Mototada Shichiri, Noriko Ishida, Taisuke Koike, Toshiki Matsuo, Hiroko Abe, Yasukazu Yoshida, Yoshihiro Nakajima
JournalJournal of agricultural and food chemistry (J Agric Food Chem) Vol. 63 Issue 30 Pg. 6715-22 (Aug 05 2015) ISSN: 1520-5118 [Electronic] United States
PMID26165358 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Blood Glucose
  • Iridoid Glucosides
  • Iridoids
  • oleuropein
Topics
  • Animals
  • Blood Glucose (metabolism)
  • Diabetes Mellitus, Type 2 (diet therapy, metabolism)
  • Diet
  • Disease Models, Animal
  • Glucose Tolerance Test
  • Humans
  • Hyperglycemia (diet therapy)
  • Iridoid Glucosides
  • Iridoids (metabolism)
  • Male
  • Mice
  • Mice, Obese

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