Abstract | BACKGROUND: MATERIALS AND METHODS: We gathered cases with histologically confirmed epithelial ovarian cancer at Sapporo Medical University Hospital from October 2010 to September 2012. Potential controls were recruited from female inpatients without any history of cancer or diabetes mellitus in different wards of the same hospital over the same period of time. Serum isoflavones, adiponectin, and insulin levels were measured in order to estimate associations with ovarian cancer risk in a case-control study. Data from 71 cases and 80 controls were analyzed with a logistic regression model adjusting for known risk factors. RESULTS: A significant reduction in ovarian cancer risk was observed for the high tertile of serum daidzein level versus the low (Ptrend<0.001). A significant reduction in ovarian cancer risk was also observed for the high tertile of serum glycitein level versus the low (Ptrend=0.005). Furthermore, a significant reduction in ovarian cancer risk was observed for the high tertile of serum adiponectin level versus the low (Ptrend=0.004). Conversely, serum insulin level showed significantly elevated risk for ovarian cancer with the high tertile versus the low Ptrend<0.001). CONCLUSIONS:
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Authors | Seiko Otokozawa, Ryoichi Tanaka, Hiroshi Akasaka, Eiki Ito, Sumiyo Asakura, Hirofumi Ohnishi, Shigeyuki Saito, Tetsuji Miura, Tsuyoshi Saito, Mitsuru Mori |
Journal | Asian Pacific journal of cancer prevention : APJCP
(Asian Pac J Cancer Prev)
Vol. 16
Issue 12
Pg. 4987-91
( 2015)
ISSN: 2476-762X [Electronic] Thailand |
PMID | 26163627
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- ADIPOQ protein, human
- Adiponectin
- Insulins
- Isoflavones
- daidzein
- glycitein
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Topics |
- Adiponectin
(blood)
- Carcinoma, Ovarian Epithelial
- Case-Control Studies
- Female
- Humans
- Insulins
(blood)
- Isoflavones
(blood)
- Logistic Models
- Middle Aged
- Neoplasms, Glandular and Epithelial
(blood)
- Ovarian Neoplasms
(blood)
- Risk Factors
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