Estimated human absorbed dose of ¹⁷⁷Lu-BPAMD based on mice data: Comparison with ¹⁷⁷Lu-EDTMP.

Abstract

In this work, the absorbed dose of human organs for (177)Lu-BPAMD was evaluated based on biodistribution studies into the Syrian mice by RADAR method and was compared with (177)Lu-EDTMP as the only clinically used Lu-177 bone-seeking agent. The highest absorbed dose for both (177)Lu-BPAMD and (177)Lu-EDTMP is observed on the bone surface with 8.007 and 4.802 mSv/MBq. Generally, (177)Lu-BPAMD has considerable characteristics compared with (177)Lu-EDTMP and can be considered as a promising agent for the bone pain palliation therapy.

• Authors: Hassan Yousefnia, Samaneh Zolghadri, Saeed Shanehsazzadeh
• Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 104 Pg. 128-35 (Oct 2015) ISSN: 1872-9800 [Electronic] England
• PMID: 26163291 (Publication Type: Comparative Study, Evaluation Study, Journal Article)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• (4-(((bis(phosphonopropyl))carbamoyl)methyl)-7,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl)acetic acid
• Diphosphonates
• Heterocyclic Compounds, 1-Ring
• Organometallic Compounds
• Organophosphorus Compounds
• Radiopharmaceuticals
• lutetium ethylenediaminetetramethylene phosphonic acid

Topics

• Absorption, Radiation
• Animals
• Bone and Bones (metabolism)
• Computer Simulation
• Diphosphonates (pharmacokinetics)
• Heterocyclic Compounds, 1-Ring (pharmacokinetics)
• Humans
• Male
• Metabolic Clearance Rate
• Mice
• Models, Biological
• Organ Specificity
• Organometallic Compounds (pharmacokinetics)
• Organophosphorus Compounds (pharmacokinetics)
• Radiation Dosage
• Radiopharmaceuticals (pharmacokinetics)
• Reproducibility of Results
• Sensitivity and Specificity
• Tissue Distribution
• Whole-Body Counting (methods)