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Synthesis and antiproliferative activity of new bioconjugates of Salinomycin with amino acid esters.

Abstract
New Salinomycin (SAL) bioconjugates with amino acid methyl esters were obtained and their antiproliferative activity against cancer cell lines including drug-resistant ones was studied. New compounds exhibit antiproliferative activity towards leukemia and doxorubicin-resistant colon adenocarcinoma cell line and are more effective and less toxic than the commonly currently used anticancer drugs.
AuthorsMichał Antoszczak, Maria Sobusiak, Ewa Maj, Joanna Wietrzyk, Adam Huczyński
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 25 Issue 17 Pg. 3511-4 (Sep 1 2015) ISSN: 1464-3405 [Electronic] England
PMID26163197 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier Ltd. All rights reserved.

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