[The effect of para-aminomethylbenzoic acid (amben) on peripheral nerve regeneration].

Abstract

Various injuries to the sciatic nerve were modelled in experiments on 60 rats and 27 dogs to study the effect of paraaminomethylbenzoic acid on its regeneration; the efficacy of amben was compared with that of other agents used widely for the treatment of injuries to nerves. It was found that amben acts on the connective tissue of the neural scar and creates favourable conditions for growth of axons from the central to the peripheral stump of the injured nerve and accelerated their maturation.

• Authors: Iu B Chaĭkovskiĭ, G N Voĭtenko, Iu N Dobrobol'skiĭ, V V Diordiĭchuk
• Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia (Patol Fiziol Eksp Ter) 1989 Sep-Oct Issue 5 Pg. 60-2 ISSN: 0031-2991 [Print] Russia (Federation)
• Vernacular Title: Vliianie paraaminometilbenzoĭnoĭ kisloty (ambena) na regeneratsiiu perifericheskogo nerva.
• PMID: 2616219 (Publication Type: English Abstract, Journal Article)

Chemical References

• para-Aminobenzoates
• 4-aminomethylbenzoic acid
• 4-Aminobenzoic Acid

Topics

• 4-Aminobenzoic Acid (pharmacology)
• Action Potentials (drug effects, physiology)
• Animals
• Disease Models, Animal
• Dogs
• Microsurgery
• Nerve Fibers (drug effects, physiology)
• Nerve Regeneration (drug effects)
• Rats
• Sciatic Nerve (drug effects, injuries, physiology)
• Time Factors
• para-Aminobenzoates