Abstract | INTRODUCTION: AREAS COVERED:
Sodium zirconium cyclosilicate (ZS-9), a novel, non-absorbed, potassium-selective cation exchanger, has demonstrated activity in acutely lowering and maintaining normal potassium levels. When used chronically, maintenance of normal serum potassium has been demonstrated for up to 1 month. Although higher doses of ZS-9 have been associated with modest increases in the rates of edema and hypokalemia, the overall adverse event rate is similar to placebo. EXPERT OPINION: The efficacy of ZS9 has been shown in patients with chronic hyperkalemia, offering promise for conditions such as HF, where optimized therapy with RAASi and MRA is often limited by a concomitant, drug-induced increase in potassium. Further, in acute hyperkalemia it has potential to become an important option by rapidly lowering potassium levels, thus delaying or potentially averting the need for emergent dialysis. While further randomized trials demonstrating improved clinical outcomes are required for both these indications, initial data suggests a promising role for this agent in the management of both acute and chronic hyperkalemia.
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Authors | Zubaid Rafique, William Frank Peacock, Frank LoVecchio, Phillip D Levy |
Journal | Expert opinion on pharmacotherapy
(Expert Opin Pharmacother)
Vol. 16
Issue 11
Pg. 1727-34
( 2015)
ISSN: 1744-7666 [Electronic] England |
PMID | 26159448
(Publication Type: Journal Article)
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Chemical References |
- Mineralocorticoid Receptor Antagonists
- Silicates
- sodium zirconium cyclosilicate
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Topics |
- Animals
- Chronic Disease
- Clinical Trials as Topic
- Heart Failure
(drug therapy)
- Humans
- Hyperkalemia
(drug therapy)
- Mineralocorticoid Receptor Antagonists
(therapeutic use)
- Renin-Angiotensin System
(drug effects)
- Silicates
(chemistry, pharmacology, therapeutic use)
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