Abstract | BACKGROUND: The effects of anti- dementia drugs on gait performance in Alzheimer disease (AD) are questionable. The objective of this meta-analysis was to examine the effects of anti- dementia drugs on the mean value and the coefficient of variation (CoV) of stride time among patients with AD while taking into account the type of drugs (i.e., acetylcholinesterase inhibitors [AChEIs] versus memantine) and the walking conditions (i.e., single versus dual-task). METHODS: RESULTS: Of the 66 identified abstracts, 5 (7.6%) were included in the meta-analysis. Inter-group comparison of between-visit change underscored a significant decrease in CoV of stride time (P<0.004) in intervention group compared to control group, whatever the pooled analysis considered, but no significant change in the mean value (P>0.06). Intra-group changes in stride time parameters following the use of anti- dementia drugs showed a significant decrease for memantine (P<0.001) and while pooling AChEIs and memantine (P<0.001) under single task condition. Under dual task condition, only AChEIs improved significantly stride time parameters (P=0.002). CONCLUSION: Anti- dementia drugs demonstrated a significant improvement of gait performance with specific class effect depending on the walking conditions and on the type of stride time parameters considered.
|
Authors | O Beauchet, C P Launay, M Montero-Odasso, C Annweiler, G Allali |
Journal | Current Alzheimer research
(Curr Alzheimer Res)
Vol. 12
Issue 8
Pg. 761-71
( 2015)
ISSN: 1875-5828 [Electronic] United Arab Emirates |
PMID | 26159199
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review)
|
Chemical References |
|
Topics |
- Alzheimer Disease
(complications, drug therapy)
- Cognition Disorders
(drug therapy, etiology)
- Gait Disorders, Neurologic
(drug therapy, etiology)
- Humans
- MEDLINE
(statistics & numerical data)
- Neuropsychological Tests
- Psychotropic Drugs
(therapeutic use)
|