Activation of the immune system in the central nervous system and oxidative stress play important roles in
traumatic brain injury (TBI)-induced
cognitive impairment.
Rhamnetin possesses anti-inflammatory and anti-oxidative properties. This study aimed to detect the possible effects of
rhamnetin on cognitive deficit, hippocampal inflammatory factors, and oxidative stress in rats with TBI. In this study, we established the
traumatic brain injury model in rats. Rats respectively received vehicle saline or
rhamnetin for 21 days. Cognitive functions were evaluated by assessing the acquisition of spatial learning and memory retention in Morris Water Maze test from day 15 to 19 post TBI. Levels of
interleukin (IL)-1β,
IL-6,
IL-8,
tumor necrosis factor a (TNF-a),
IL-10, and nuclear factor κB (NF-κB) in hippocampal homogenate were measured using ELISA. Oxidative stress was analysed by investigating the activities of MDA, H2O2, SOD, and GSH-Px. We found that
rhamnetin significantly improved
cognitive impairment in rats with TBI, and inhibited the inflammatory response and oxidative stress in the hippocampus. The results suggested that
rhamnetin could enhance the recovery of cognitive deficits induced by TBI, and that its mechanism might be associated with the inhibition of
inflammation and oxidative stress in the hippocampus.