Pharmacology of alpha/beta arteether--a potential antimalarial drug.

Abstract	Pharmacological studies on alpha/beta arteether (a 30:70 mixture of isomers), a potential drug for the treatment of cerebral malaria, were carried out in experimental animals by giving the drug in arachis oil suspension. The compound appears to be devoid of significant pharmacological activity on the central nervous, cardiovascular and urinary systems. It lacks an anti-inflammatory response in rats up to 50 mg/kg intramuscularly but at 50-200 mg/kg it has some antianaphylactic potential.
Authors	K Kar, A Nath, R Bajpai, G P Dutta, R A Vishwakarma
Journal	Journal of ethnopharmacology (J Ethnopharmacol) Vol. 27 Issue 3 Pg. 297-305 (Dec 1989) ISSN: 0378-8741 [Print] Ireland
PMID	2615435 (Publication Type: Journal Article)
Chemical References	Antimalarials Artemisinins Sesquiterpenes artemotil
Topics	Animals Antimalarials (pharmacology, toxicity) Artemisinins Behavior, Animal (drug effects) Blood Pressure (drug effects) Cats Diuresis (drug effects) Female Heart Rate (drug effects) Lethal Dose 50 Male Mice Passive Cutaneous Anaphylaxis (drug effects) Rats Sesquiterpenes (pharmacology, toxicity)

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