Receptor selective ruthenium-somatostatin photosensitizer for cancer targeted photodynamic applications.

Abstract

The efficient conjugation of a ruthenium complex and the peptide hormone somatostatin is presented. The resultant biohybrid offers valuable features for photodynamic therapy such as remarkable cellular selectivity, rapid cell uptake by receptor-mediated endocytosis, efficient generation of (1)O2 upon irradiation, potent phototoxicity as well as low cytotoxicity in the "off"-state.

• Authors: Tao Wang, Natalia Zabarska, Yuzhou Wu, Markus Lamla, Stephan Fischer, Katharina Monczak, David Y W Ng, Sven Rau, Tanja Weil
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 51 Issue 63 Pg. 12552-5 (Aug 14 2015) ISSN: 1364-548X [Electronic] England
• PMID: 26153573 (Publication Type: Journal Article)

Chemical References

• Coordination Complexes
• Photosensitizing Agents
• Receptors, Somatostatin
• Singlet Oxygen
• Somatostatin
• Ruthenium

Topics

• Cell Line, Tumor
• Cell Survival (drug effects)
• Coordination Complexes (chemistry, therapeutic use, toxicity)
• Endocytosis
• Humans
• Microscopy, Confocal
• Neoplasms (drug therapy)
• Photochemotherapy
• Photosensitizing Agents (chemistry, therapeutic use, toxicity)
• Receptors, Somatostatin (metabolism)
• Ruthenium (chemistry)
• Singlet Oxygen (metabolism)
• Somatostatin (chemistry)
• Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization