Abstract | BACKGROUND AND OBJECTIVES:
Endothelin A receptor antagonists (ERAs) decrease residual albuminuria in patients with diabetic kidney disease; however, their clinical utility may be limited by fluid retention. Consequently, the primary objective of this study was to identify predictors for ERA-induced fluid retention among patients with type 2 diabetes and CKD. A secondary objective was to determine if the degree of fluid retention necessarily correlated with the magnitude of albuminuria reduction in those patients receiving ERAs. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: RESULTS: CONCLUSIONS: In the Reducing Residual Albuminuria in Subjects With Diabetes and Nephropathy With Atrasentan/JAPAN trials, atrasentan-associated fluid retention was more likely in patients with diabetes and nephropathy who had lower eGFR or received a higher dose of atrasentan. Finding that albuminuria reduction was not associated with changes in body weight and Hb suggests that the albuminuria-reducing efficacy of atrasentan is not impaired by fluid retention.
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Authors | Donald E Kohan, Hiddo J Lambers Heerspink, Blai Coll, Dennis Andress, John J Brennan, Dalane W Kitzman, Ricardo Correa-Rotter, Hirofumi Makino, Vlado Perkovic, Fan Fan Hou, Giuseppe Remuzzi, Sheldon W Tobe, Robert Toto, Hans-Henrik Parving, Dick de Zeeuw |
Journal | Clinical journal of the American Society of Nephrology : CJASN
(Clin J Am Soc Nephrol)
Vol. 10
Issue 9
Pg. 1568-74
(Sep 04 2015)
ISSN: 1555-905X [Electronic] United States |
PMID | 26153128
(Publication Type: Clinical Trial, Phase II, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 by the American Society of Nephrology. |
Chemical References |
- Endothelin Receptor Antagonists
- Glycated Hemoglobin A
- Pyrrolidines
- Natriuretic Peptide, Brain
- Creatinine
- Atrasentan
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Topics |
- Aged
- Albuminuria
(drug therapy, etiology, physiopathology)
- Atrasentan
- Body Fluids
(drug effects)
- Creatinine
(urine)
- Diabetes Mellitus, Type 2
(complications)
- Diabetic Nephropathies
(complications, physiopathology)
- Double-Blind Method
- Endothelin Receptor Antagonists
(administration & dosage, adverse effects)
- Female
- Glomerular Filtration Rate
- Glycated Hemoglobin
(metabolism)
- Humans
- Male
- Middle Aged
- Natriuretic Peptide, Brain
(blood)
- Pyrrolidines
(administration & dosage, adverse effects)
- Weight Gain
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