Novasure impedance control system versus microwave endometrial ablation for the treatment of dysfunctional uterine bleeding: a double-blind, randomized controlled trial.

Abstract

PURPOSE OF INVESTIGATION:

To compare the efficacy and safety of two different second-generation ablation devices, Novasure impedance control system and microwave endometrial ablation (MEA), in cases of abnormal uterine bleeding (AUB).

MATERIALS AND METHODS:

This is a randomized controlled trial that took place in a single Gynecological Department of a University Hospital. Sixty-six women with dysfunctional uterine bleeding (DUB), unresponsive to medical treatment, were included in the trial. The ratio of women allocated to bipolar radio-frequency ablation or MEA was 1:1. Follow-up assessments were carried out at three and 12 months post-ablation. The present main outcome measure was amenorrhea rates 12-months post-treatment.

RESULTS:

The rate of amenorrhea at 12-months post-ablation was significantly higher in women treated by Novasure (25/33; 75.8%) as compared to those treated by MEA (8/33; 24.2%) (rate difference: +51.5%, 95% CI: +27.8 to +67.7).

CONCLUSION:

In women with DUB, endometrial ablation with Novasure bipolar radiofrequency impedance-controlled system is associated with increased rates of amenorrhea at 12-months post-treatment as compared to the MEA method.

• Authors: D Athanatos, G Pados, C A Venetis, P Stamatopoulos, D Rousso, D Tsolakidis, C P Stamatopoulos, B C Tarlatzis
• Journal: Clinical and experimental obstetrics & gynecology (Clin Exp Obstet Gynecol) Vol. 42 Issue 3 Pg. 347-51 ( 2015) ISSN: 0390-6663 [Print] Singapore
• PMID: 26152008 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Topics

• Adult
• Amenorrhea
• Catheter Ablation (methods)
• Double-Blind Method
• Electric Impedance (therapeutic use)
• Endometrial Ablation Techniques
• Female
• Humans
• Menorrhagia (surgery)
• Metrorrhagia (surgery)
• Microwaves (therapeutic use)
• Middle Aged
• Treatment Outcome