HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Beneficial renal effects of CS-905, a novel dihydropyridine calcium blocker, in SHR.

Abstract
CS-905 is a potent dihydropyridine calcium blocker that has a gradual and long-lasting antihypertensive action with little tachycardia in SHR. In this study, we investigated chronic and acute effects of CS-905 on renal functions in SHR. To examine the chronic effects, 23 week-old male SHR were treated with CS-905 (1 or 3 mg/kg/day, p.o.) or 0.3% CMC (carboxymethylcellulose). After the 15 week-treatment, the agent dose-relatedly lowered systolic blood pressure measured 24 hr after the final administration (184 +/- 2 and 173 +/- 3 mmHg at 1 and 3 mg/kg/day vs. 218 +/- 4 mmHg for the control group). Natriuresis and the reduction of urinary protein excretion were also observed in the CS-905 treated groups. Urinary NAG (N-acetyl-beta-D-glucosaminidase) activity tended to decrease, but not significantly. Histopathological changes observed in the SHR kidney were reduced by chronic treatment with CS-905. On a single oral administration in 38 week-old SHR, CS-905 caused natriuresis at a dose of 3 mg/kg, but did not affect urinary protein excretion and urinary NAG activity. These effects of CS-905 on renal functions may be beneficial in the treatment of hypertension.
AuthorsK Oizumi, H Nishino, M Miyamoto, J Fukushige, M Fukami, H Koike
JournalJapanese journal of pharmacology (Jpn J Pharmacol) Vol. 51 Issue 4 Pg. 501-8 (Dec 1989) ISSN: 0021-5198 [Print] Japan
PMID2615042 (Publication Type: Journal Article)
Chemical References
  • Azetines
  • Calcium Channel Blockers
  • Dihydropyridines
  • Azetidinecarboxylic Acid
  • Acetylglucosaminidase
  • azelnidipine
Topics
  • Acetylglucosaminidase (urine)
  • Animals
  • Azetidinecarboxylic Acid (analogs & derivatives, pharmacology)
  • Azetines (pharmacology)
  • Blood Pressure (drug effects)
  • Calcium Channel Blockers (therapeutic use)
  • Dihydropyridines (pharmacology)
  • Hypertension (drug therapy, pathology, physiopathology)
  • Kidney (pathology, physiopathology)
  • Kidney Glomerulus (pathology)
  • Male
  • Proteinuria (physiopathology)
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred WKY

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: