Abstract |
CS-905 is a potent dihydropyridine calcium blocker that has a gradual and long-lasting antihypertensive action with little tachycardia in SHR. In this study, we investigated chronic and acute effects of CS-905 on renal functions in SHR. To examine the chronic effects, 23 week-old male SHR were treated with CS-905 (1 or 3 mg/kg/day, p.o.) or 0.3% CMC ( carboxymethylcellulose). After the 15 week-treatment, the agent dose-relatedly lowered systolic blood pressure measured 24 hr after the final administration (184 +/- 2 and 173 +/- 3 mmHg at 1 and 3 mg/kg/day vs. 218 +/- 4 mmHg for the control group). Natriuresis and the reduction of urinary protein excretion were also observed in the CS-905 treated groups. Urinary NAG ( N-acetyl-beta-D-glucosaminidase) activity tended to decrease, but not significantly. Histopathological changes observed in the SHR kidney were reduced by chronic treatment with CS-905. On a single oral administration in 38 week-old SHR, CS-905 caused natriuresis at a dose of 3 mg/kg, but did not affect urinary protein excretion and urinary NAG activity. These effects of CS-905 on renal functions may be beneficial in the treatment of hypertension.
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Authors | K Oizumi, H Nishino, M Miyamoto, J Fukushige, M Fukami, H Koike |
Journal | Japanese journal of pharmacology
(Jpn J Pharmacol)
Vol. 51
Issue 4
Pg. 501-8
(Dec 1989)
ISSN: 0021-5198 [Print] Japan |
PMID | 2615042
(Publication Type: Journal Article)
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Chemical References |
- Azetines
- Calcium Channel Blockers
- Dihydropyridines
- Azetidinecarboxylic Acid
- Acetylglucosaminidase
- azelnidipine
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Topics |
- Acetylglucosaminidase
(urine)
- Animals
- Azetidinecarboxylic Acid
(analogs & derivatives, pharmacology)
- Azetines
(pharmacology)
- Blood Pressure
(drug effects)
- Calcium Channel Blockers
(therapeutic use)
- Dihydropyridines
(pharmacology)
- Hypertension
(drug therapy, pathology, physiopathology)
- Kidney
(pathology, physiopathology)
- Kidney Glomerulus
(pathology)
- Male
- Proteinuria
(physiopathology)
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY
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