Abstract | BACKGROUND: METHODS: The effects of N-methanocarbathymidine were evaluated and compared to acyclovir using guinea pig models of acute and recurrent infection. For acute disease following intravaginal inoculation of 10(6 )pfu HSV-2 (MS strain), animals were treated intraperitoneally beginning 24 h post- infection, and the effects on disease severity, vaginal virus replication, subsequent recurrences, and latent virus loads were evaluated. For evaluation of recurrent infection, animals were treated for 21 days beginning 14 days after infection and disease recurrence and recurrent shedding were evaluated. RESULTS: CONCLUSION:
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Authors | David I Bernstein, Fernando J Bravo, Derek A Pullum, Hui Shen, Mei Wang, Aquilur Rahman, Robert I Glazer, Rhonda D Cardin |
Journal | Antiviral chemistry & chemotherapy
(Antivir Chem Chemother)
Vol. 24
Issue 1
Pg. 19-27
(Feb 2015)
ISSN: 2040-2066 [Electronic] England |
PMID | 26149263
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | © The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav. |
Chemical References |
- Antiviral Agents
- (north)-methanocarbathymidine
- Thymidine
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Topics |
- Acute Disease
- Animals
- Antiviral Agents
(pharmacokinetics, pharmacology, therapeutic use)
- Disease Models, Animal
- Female
- Guinea Pigs
- Herpes Genitalis
(drug therapy, virology)
- Herpesvirus 2, Human
(drug effects, physiology)
- Recurrence
- Thymidine
(analogs & derivatives, pharmacokinetics, pharmacology, therapeutic use)
- Virus Shedding
(drug effects)
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