Abstract | BACKGROUND: METHODS: Twenty-three consecutive patients with symptomatic cystitis after external radiotherapy for PCa were enrolled. Patients underwent bladder instillation therapy with HA and CS weekly for the first month and, afterwards, on week 6, 8 and 12. Nocturnal voiding frequency was assessed by item 3 (Q3) of the Interstitial Cystitis Symptoms Index (ICSI) and item 2 (Q2) of the Interstitial Cystitis Problem Index (ICPI). Data were analyzed with paired-samples T-test and adjusted for age. RESULTS: Eighteen patients (78%) reported about nocturia. Pre- and post-treatment ICSI-Q3 was 2.13 ± 0.28 and 1.61 ± 0.21 (-24.4%, p = 0.001). With logistic regression analysis, both age and baseline ICSI-Q3 had a significant impact on nocturnal voiding frequency (r = 0.293, p = 0.011 and r = 0.970, p < 0.001). Pre- and post-treatment ICPI-Q2 was 1.87 ± 0.26 and 1.30 ± 0.25 (-30.5%, p = 0.016); logistic regression analysis was without significant findings. CONCLUSION:
Bladder instillation treatment with a combination of HA and CS was effective in reducing nocturnal voiding frequency in men with post-radiation bladder pain for PCa. Randomized, controlled trials with sham treatment are needed to confirm our result.
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Authors | Mauro Gacci, Omar Saleh, Claudia Giannessi, Beatrice Detti, Lorenzo Livi, Eleonora Monteleone Pasquetti, Tatiana Masoni, Enrico Finazzi Agro, Vincenzo Li Marzi, Andrea Minervini, Marco Carini, Stavros Gravas, Matthias Oelke, Sergio Serni |
Journal | BMC urology
(BMC Urol)
Vol. 15
Pg. 65
(Jul 07 2015)
ISSN: 1471-2490 [Electronic] England |
PMID | 26148853
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Drug Combinations
- chondroitin sulfate, sodium hyaluronate drug combination
- Hyaluronic Acid
- Chondroitin Sulfates
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Topics |
- Administration, Intravesical
- Aged
- Chondroitin Sulfates
(administration & dosage)
- Cystitis
(drug therapy, etiology)
- Drug Combinations
- Humans
- Hyaluronic Acid
(administration & dosage)
- Male
- Nocturia
(drug therapy, etiology)
- Pilot Projects
- Prospective Studies
- Prostatic Neoplasms
(complications, radiotherapy)
- Radiation Injuries
(drug therapy, etiology)
- Radiotherapy, Conformal
(adverse effects)
- Treatment Outcome
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