Abstract | INTRODUCTION: METHODS: 84 consecutively recruited ALF patients were grouped according to the outcome of ALF (spontaneous recovery: SR; transplantation or death: NSR). TSH, free thyroxine (fT4), free triiodothyronine (fT3), T4, and T3 were determined. RESULTS: More than 50% of patients with ALF presented with abnormal thyroid parameters. These patients had greater risk for an adverse outcome than euthyroid patients. SR patients had significantly higher TSH, T4, and T3 concentrations than NSR patients. Albumin concentrations were significantly higher in SR than in NSR. In vitro T3 treatment was not able to rescue primary human hepatocytes from acetaminophen induced changes in mRNA expression. CONCLUSIONS: In patients with ALF, TSH and total thyroid hormone levels differed significantly between SR patients and NSR patients. This might be related to diminished liver-derived transport proteins, such as albumin, in more severe forms of ALF. Thyroid parameters may serve as additional indicators of ALF severity.
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Authors | Olympia Anastasiou, Svenja Sydor, Jan-Peter Sowa, Paul Manka, Antonios Katsounas, Wing-Kin Syn, Dagmar Führer, Robert K Gieseler, Lars P Bechmann, Guido Gerken, Lars C Moeller, Ali Canbay |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 7
Pg. e0132189
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 26147961
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Triiodothyronine
- Thyrotropin
- Thyroxine
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Topics |
- Adult
- Female
- Humans
- Liver Failure, Acute
(blood, mortality, surgery)
- Liver Transplantation
- Male
- Retrospective Studies
- Thyrotropin
(blood)
- Thyroxine
(blood)
- Triiodothyronine
(blood)
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