An NIR-triggered and thermally responsive drug delivery platform through DNA/copper sulfide gates.

Abstract

Nanomaterials for effective drug delivery require zero pre-release and on-demand release of therapeutic drugs. In this work we demonstrate a novel drug delivery system composed of a mesoporous silica platform conjugated to CuS nanoparticles with two complementary DNA sequences. CuS nanoparticles act as both gatekeepers preventing pre-release of drugs and photothermal agents for effective killing of cancer cells. This system exhibits temperature and NIR-responsive DOX release, with an additional accelerated release rate with GSH treatment. Therefore, it can act as an effective anticancer drug delivery carrier with triggered drug release and efficient anti-cancer effect in vitro after NIR irradiation.

• Authors: Lei Zhang, Yecheng Li, Zexun Jin, Jimmy C Yu, King Ming Chan
• Journal: Nanoscale (Nanoscale) Vol. 7 Issue 29 Pg. 12614-24 (Aug 07 2015) ISSN: 2040-3372 [Electronic] England
• PMID: 26147639 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Drug Carriers
• Oligonucleotides
• Copper
• Doxorubicin
• DNA
• Glutathione
• cupric sulfide

Topics

• Antineoplastic Agents (chemistry, metabolism, toxicity)
• Base Sequence
• Cell Survival (drug effects)
• Copper (chemistry)
• DNA (chemistry)
• Doxorubicin (chemistry, metabolism, toxicity)
• Drug Carriers (chemistry)
• Drug Liberation
• Glutathione (chemistry)
• HeLa Cells
• Humans
• Infrared Rays
• MCF-7 Cells
• Microscopy, Confocal
• Nanoparticles (chemistry, ultrastructure)
• Oligonucleotides (chemistry)
• Temperature