Abstract | OBJECTIVES: To analyze the efficacy of hyperbaric oxygen for the treatment of radiation-induced hemorrhagic cystitis and to identify factors associated with successful treatment. METHODS: Clinical records from 176 patients with refractory radiation-induced hemorrhagic cystitis treated at the Portuguese Navy Center for Underwater and Hyperbaric Medicine, during a 15-year period, were retrospectively analyzed. Evolution of macroscopic hematuria was used to analyze treatment efficacy and correlated with other external variables. RESULTS: From a total of 176 treated patients, 23.9% evidenced other radiation-induced soft tissue lesions. After an average on 37 sessions, 89.8% of patients showed resolution of hematuria, with only 1.7% of adverse events. In our sample, hematuria resolution after treatment with hyperbaric oxygen was statistically associated to the need for transfusion therapy (P = 0.026) and the number of sessions of hyperbaric oxygen (P = 0.042). No relationship was found with the remaining variables. CONCLUSIONS: Refractory radiation-induced hemorrhagic cystitis can be successfully and safely treated with hyperbaric oxygen. Treatment effectiveness seems to be correlated with the need for transfusion therapy and the number of sessions performed.
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Authors | Tiago M Ribeiro de Oliveira, António J Carmelo Romão, Francisco M Gamito Guerreiro, Tomé M Matos Lopes |
Journal | International journal of urology : official journal of the Japanese Urological Association
(Int J Urol)
Vol. 22
Issue 10
Pg. 962-6
(Oct 2015)
ISSN: 1442-2042 [Electronic] Australia |
PMID | 26146963
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 The Japanese Urological Association. |
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Blood Transfusion
- Cystitis
(etiology, therapy)
- Female
- Hematuria
(etiology, therapy)
- Humans
- Hyperbaric Oxygenation
(methods)
- Male
- Middle Aged
- Prostatic Neoplasms
(radiotherapy)
- Radiation Injuries
(etiology, therapy)
- Retreatment
- Retrospective Studies
- Treatment Outcome
- Urinary Bladder
(radiation effects)
- Uterine Cervical Neoplasms
(radiotherapy)
- Young Adult
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