Abstract | OBJECTIVE: METHODS: The study included 40 OSAS patients and 40 age- sex- and body mass index-matched healthy controls. Serum YKL-40 levels were detected by enzyme-linked immunosorbent assay. CIMT was measured by B-mode ultrasound. RESULTS: The patients with OSAS had significantly increased CIMT and higher YKL-40 and high sensitivity C-reactive protein ( hsCRP) levels than those of the controls. CIMT was strongly correlated with serum YKL-40 levels (r=0.694, p<0.001), hsCRP (r=0.622, p<0.001), age (r=0.525, p=0.001), and weakly correlated with apnea-hypopnea index (AHI) (r=0.365, p=0.021) and the percentage of recording time spent (PRTS) of oxygen saturation<90% (r=0.488, p=0.001). Moreover, it was detected that serum YKL-40 levels were strongly correlated with AHI (r=0.617, p<0.001), and weakly correlated with SaO2<90% of PRTS (r=0.394, p=0.012) and hsCRP (r=0.486, p=0.001). In multiple regression analyses, age and serum levels of YKL-40 and hsCRP were found to be independent predictors of CIMT. CONCLUSION: In patients with OSAS, CIMT was increased. This increase was associated with serum YKL-40 level. Increased serum level of YKL-40 may be an early predictor of atherosclerosis development in patients with OSAS.
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Authors | Eftal Murat Bakırcı, Edhem Ünver, Hüsnü Değirmenci, Tülay Kıvanç, Murat Günay, Hikmet Hamur, Mutlu Büyüklü, Gökhan Ceyhun, Ergun Topal, Taha Abdulkadir Çoban |
Journal | Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir
(Turk Kardiyol Dern Ars)
Vol. 43
Issue 4
Pg. 333-9
(Jun 2015)
ISSN: 1016-5169 [Print] Turkey |
PMID | 26142786
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adipokines
- CHI3L1 protein, human
- Chitinase-3-Like Protein 1
- Lectins
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Topics |
- Adipokines
(blood)
- Adult
- Atherosclerosis
(blood, complications, diagnosis, epidemiology)
- Carotid Intima-Media Thickness
- Chitinase-3-Like Protein 1
- Female
- Humans
- Lectins
(blood)
- Male
- Middle Aged
- Polysomnography
- Prospective Studies
- Sleep Apnea, Obstructive
(blood, complications, diagnosis, epidemiology)
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