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Riparin B, a Synthetic Compound Analogue of Riparin, Inhibits the Systemic Inflammatory Response and Oxidative Stress in Mice.

Abstract
The aim of our study was to evaluate the anti-inflammatory, anti-nociceptive, and anti-oxidant action of Riparin B in vivo. We performed experiments in which we induced paw edema by carrageenan and other mediators, carrageenan-induced peritonitis and the level of myeloperoxidase (MPO) activity, pro-inflammatory cytokines (TNF-α and IL-1β), malondialdehyde (MDA) acid, and glutathione (GSH) from the peritoneal fluid. We also performed behavior tests such as acetic acid-induced writhing, formalin-induced linking, and the hot plate test. Among the doses tested of the Riparin B (1, 3, and 10 mg/kg), the dose of 10 mg/kg showed the strongest effect, and this dose was able to reduce the paw edema induced by carrageenan, dextran, histamine serotonin, bradykinin, 48/80, and PGE2. Similarly, the Riparin B in the same dose reduced cell migration and significantly decreased the nociception induced by formalin and acetic acid and reversed the parameters of the oxidative stress. Thus, we can infer that Riparin B exhibits anti-inflammatory, anti-nociceptive, and anti-oxidant actions in vivo.
AuthorsRenata Fortes Santiago, Tarcisio Vieira de Brito, Jordana Maia Dias, Genilson José Dias Jr, José Simião da Cruz Jr, Jalles Arruda Batista, Renan Oliveira Silva, Marcellus H L P Souza, Ronaldo de Albuquerque Ribeiro, Stanley Juan Chavez Gutierrez, Rivelilson M Freitas, Jand-Venes R Medeiros, André Luiz Dos Reis Barbosa
JournalInflammation (Inflammation) Vol. 38 Issue 6 Pg. 2203-15 (Dec 2015) ISSN: 1573-2576 [Electronic] United States
PMID26140904 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Analgesics
  • Anti-Inflammatory Agents
  • Antioxidants
  • Benzamides
  • Cytokines
  • Inflammation Mediators
  • N-(2-(3,4-dimethoxyphenyl)ethyl)benzamide
  • Phenethylamines
  • Malondialdehyde
  • Carrageenan
  • Peroxidase
  • Glutathione
Topics
  • Analgesics (pharmacology)
  • Animals
  • Anti-Inflammatory Agents (pharmacology)
  • Antioxidants (pharmacology)
  • Benzamides (pharmacology)
  • Carrageenan
  • Cytokines (immunology, metabolism)
  • Disease Models, Animal
  • Edema (chemically induced, immunology, metabolism, prevention & control)
  • Glutathione (metabolism)
  • Inflammation Mediators (immunology, metabolism)
  • Male
  • Malondialdehyde (metabolism)
  • Mice
  • Neutrophil Infiltration (drug effects)
  • Nociceptive Pain (chemically induced, metabolism, prevention & control)
  • Oxidative Stress (drug effects)
  • Peritonitis (chemically induced, immunology, metabolism, prevention & control)
  • Peroxidase (metabolism)
  • Phenethylamines (pharmacology)
  • Time Factors

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