Abstract |
Ten patients with relapsing high grade brain gliomas and one patient with low grade glioma were studied with a monoclonal antibody (H17E2) against placental alkaline phosphatase. In addition 2 patients with relapsing high grade glioma were studied with a non specific antibody (4D513/2118). 1 mCi of Iodine-131-labelled H17E2 was administered intracarotidly (i.c.) in two, and intravenously (i.v.) in 9 patients. Immunoscintigrams were taken at 0, 2, 24, 48 and 72 hours. Radioactivity was monitored in blood and urine. Tumour/non-tumour ratios were estimated (max. 2.45). All high grade gliomas receiving specific antibody irrespective of the route of administration, gave a positive immunoscintigraphic pattern, increasing in intensity with time. Disappearance of radioactivity in blood was biexpontential with a long component over 30 hours. Urinary excretion of radioactivity ranged from 3.7-21.7% of administered dose/day. The patient with low grade glioma and the patients receiving non specific monoclonal antibody showed a negative pattern, a fast blood clearance and a high urinary excretion. We conclude that a) Iodine-131 labelled H17E2 proved to be stable in vivo and produced satisfactory tumour localisation and b) i.v. route was as good as i.c.
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Authors | D V Skarlos, J Malamitsi, G B Sivolapenko, N Demakopoulos, G Avgoustatos, C Koutoulidis, A A Epenetos |
Journal | The International journal of biological markers
(Int J Biol Markers)
1989 Jul-Sep
Vol. 4
Issue 3
Pg. 135-41
ISSN: 0393-6155 [Print] United States |
PMID | 2614081
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Biomarkers, Tumor
- Iodine Radioisotopes
- Alkaline Phosphatase
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Topics |
- Alkaline Phosphatase
(immunology)
- Antibodies, Monoclonal
(administration & dosage)
- Biomarkers, Tumor
(immunology)
- Brain Neoplasms
(diagnosis, diagnostic imaging, immunology)
- Glioma
(diagnosis, diagnostic imaging, immunology)
- Humans
- Iodine Radioisotopes
- Kinetics
- Radionuclide Imaging
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