Lack of common haplotype among four family members with late-onset Kaposi's sarcoma.

Abstract

Kaposi's sarcoma is associated with an increased frequency of HLA-DR5. The hypothesized model of a susceptibility gene in linkage disequilibrium with DR5 may be tested by haplotype analysis in familial Kaposi's sarcoma. Our finding of no common haplotype among afflicted members of a family provides evidence against the hypothesized linkage.

• Authors: J R Neefe, J A Treat, B K Chun, P S Schein, A H Johnson
• Journal: Journal of immunogenetics (J Immunogenet) Vol. 16 Issue 3 Pg. 247-50 (Jun 1989) ISSN: 0305-1811 [Print] England
• PMID: 2614074 (Publication Type: Case Reports, Journal Article)

Chemical References

• HLA-DR5 Antigen

Topics

• Aged
• Aged, 80 and over
• Disease Susceptibility
• Female
• HLA-DR5 Antigen (genetics)
• Haplotypes
• Histocompatibility Testing
• Humans
• Male
• Pedigree
• Sarcoma, Kaposi (genetics, immunology)