Development and preclinical evaluation of a new galactomannan-based dressing with antioxidant properties for wound healing.

Abstract	We describe a novel wound dressing (HR006) with two components: a lyophilized matrix of the galactomannan from locust bean gum (LBG) and an antioxidant hydration solution (AHsol) containing curcumin and N-acetyl-L-cysteine (NAC). Physico-structural analyses of the LBG matrix revealed homogeneous interconnected pores with high absorbing capacity showing excellent properties for moist wound care (MWC). In an in vitro oxidative stress fibroblast injury model, the AHsol showed relevant protective effects reducing intracellular reactive oxygen species (ROS) production, rescuing cell viability, and regulating expression of inflammation-related genes (COX-2, TNF-α, IL-1α, IL-1β). The new dressing showed good biocompatibility profile as demonstrated by cytotoxicity, hemocompatibility, and skin irritation tests. Moreover, in an in vivo skin wound model in pigs, this dressing enhanced the production of healthy and organized granulation tissue and re-epithelization. In summary, HR006 exhibits significant antioxidant activity, good biocompatibility, and excellent repair capabilities improving tissue remodeling and the healing of wounds.
Authors	Begoña Castro, Teodoro Palomares, Iker Azcoitia, Felix Bastida, Maite del Olmo, Javier J Soldevilla, Ana Alonso-Varona
Journal	Histology and histopathology (Histol Histopathol) Vol. 30 Issue 12 Pg. 1499-512 (Dec 2015) ISSN: 1699-5848 [Electronic] Spain
PMID	26140672 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antioxidants Cytokines Galactans Irritants Mannans Plant Gums Reactive Oxygen Species galactomannan Curcumin locust bean gum Acetylcysteine Galactose
Topics	Acetylcysteine (pharmacology) Animals Antioxidants (administration & dosage, therapeutic use) Bandages (adverse effects) Curcumin (pharmacology) Cytokines (biosynthesis, genetics) Fibroblasts (drug effects) Galactans Galactose (analogs & derivatives) Humans Inflammation (drug therapy, genetics) Irritants Mannans (administration & dosage, adverse effects, therapeutic use) Materials Testing Oxidative Stress (drug effects) Plant Gums Reactive Oxygen Species (metabolism) Sus scrofa Wound Healing (drug effects)

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