Abstract | SIGNIFICANCE:
Nitric oxide (NO) is a critical signaling molecule marked by complex chemistry and varied biological responses depending on the context of the redox environment. In the setting of inflammation, NO can not only contribute to tissue injury and be causative of oxidative damage but can also signal as an adaptive molecule to limit inflammatory signaling in multiple cell types and tissues. RECENT ADVANCES: An advance in our understanding of NO biology was the recognition of the nitrate- nitrite-NO axis, whereby nitrate (predominantly from dietary sources) could be converted to nitrite and nitrite could be reduced to NO. CRITICAL ISSUES: FUTURE DIRECTIONS: These preclinical and clinical investigations set up further clinical trials and studies that elucidate the endogenous role this pathway plays in protection against inflammatory signaling.
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Authors | Paul Waltz, Daniel Escobar, Ana Maria Botero, Brian S Zuckerbraun |
Journal | Antioxidants & redox signaling
(Antioxid Redox Signal)
Vol. 23
Issue 4
Pg. 328-39
(Aug 01 2015)
ISSN: 1557-7716 [Electronic] United States |
PMID | 26140517
(Publication Type: Journal Article, Review)
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Chemical References |
- Nitrates
- Nitrites
- Reactive Oxygen Species
- Nitric Oxide
- Nitrite Reductases
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Topics |
- Animals
- Humans
- Inflammation
(metabolism)
- Nitrates
(metabolism)
- Nitric Oxide
(metabolism)
- Nitrite Reductases
(metabolism)
- Nitrites
(metabolism)
- Oxidation-Reduction
- Reactive Oxygen Species
(metabolism)
- Signal Transduction
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