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Epigenetic Mechanisms Leading to Overexpression of HMGA Proteins in Human Pituitary Adenomas.

Abstract
Overexpression of the high-mobility group A (HMGA)1 and HMGA2 proteins is a feature of all human pituitary adenoma (PAs) subtypes. However, amplification and/or rearrangement of the HMGA2 have been described in human prolactinomas, but rarely in other pituitary subtypes, and no genomic amplification of HMGA1 was detected in PAs. Here, we summarize the functional role of HMGA proteins in pituitary tumorigenesis and the epigenetic mechanisms contributing to HMGA overexpression in these tumors focusing on recent studies indicating a critical role of non-coding RNAs in modulating HMGA protein levels.
AuthorsDaniela D'Angelo, Francesco Esposito, Alfredo Fusco
JournalFrontiers in medicine (Front Med (Lausanne)) Vol. 2 Pg. 39 ( 2015) ISSN: 2296-858X [Print] Switzerland
PMID26137461 (Publication Type: Journal Article, Review)

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