Use of Octreotide for the Management of Chyle Fistula Following Neck Dissection.

Abstract

IMPORTANCE:

Chyle fistula is an uncommon complication of neck surgery. A variety of management strategies have been described, including diet restriction, parenteral nutrition, use of pressure dressings, and revision surgery. Octreotide has been used with success in patients with neck and thoracic chyle fistulas, but data regarding efficacy in neck chyle fistulas are lacking.

OBJECTIVE:

To evaluate the efficacy of octreotide for use in patients with postoperative chyle fistulas.

DESIGN, SETTING, AND PARTICIPANTS:

Retrospective review of 12 patients who received octreotide for neck chylous fistula after neck dissection was performed during the period 2004 through 2014 at 2 tertiary care academic hospitals.

EXPOSURES:

Patients with postoperative neck chyle fistulas were given a restricted diet and subcutaneous octreotide.

MAIN OUTCOMES AND MEASURES:

The main outcome was fistula closure rate, defined as fistula resolution without surgical intervention. Secondary outcomes of fistula duration (days from detection until resolution), length of hospital stay (surgery to discharge), and treatment complications were also examined.

RESULTS:

All 12 patients had resolution of their neck chyle fistula with octreotide therapy without need for revision surgery. Mean (SD) hospital stay was 8.7 (4.76) days, with a range of 3 to 18 days. The chyle fistula resolved after a mean (range) 5.5 (2-11) days. Self-resolving nausea was encountered in 1 patient from octreotide use, and 1 patient developed a salivary fistula as a result of the chylous fistula.

CONCLUSIONS AND RELEVANCE:

In these patients, octreotide was safe and effective in resolving neck chylous fistulas. Octreotide therapy appears superior to traditional conservative measures of diet restriction and pressure dressings when compared with literature rates. A prospective study is needed to confirm results, but octreotide therapy should be considered as first-line conservative management for neck chyle fistulas that occur after neck surgery.

• Authors: Mark S Swanson, Rachael L Hudson, Nipun Bhandari, Uttam K Sinha, Dennis R Maceri, Niels Kokot
• Journal: JAMA otolaryngology-- head & neck surgery (JAMA Otolaryngol Head Neck Surg) Vol. 141 Issue 8 Pg. 723-7 (Aug 2015) ISSN: 2168-619X [Electronic] United States
• PMID: 26135979 (Publication Type: Journal Article)

Chemical References

• Gastrointestinal Agents
• Octreotide

Topics

• Adult
• Aged
• Chyle
• Female
• Fistula (drug therapy, etiology)
• Gastrointestinal Agents (therapeutic use)
• Head and Neck Neoplasms (pathology, surgery)
• Humans
• Length of Stay
• Male
• Middle Aged
• Neck Dissection (adverse effects)
• Octreotide (therapeutic use)
• Retrospective Studies
• Treatment Outcome