Impact of Mutations at Amino Acid 70 in Hepatitis C Virus (HCV) Genotype 1b Core Region on Hepatocarcinogenesis following Eradication of HCV RNA.

Abstract

The impact of the HCV genotype 1b core amino acid (aa) 70 mutant on the cumulative rate of hepatocellular carcinoma following eradication of HCV RNA by antiviral therapy was investigated with the Q-Invader assay. Multivariate analysis based on 649 patients indicated that a core aa70 Q-Invader mutant level ≥20% is a predictor of hepatocellular carcinoma.

• Authors: Norio Akuta, Fumitaka Suzuki, Masahiro Kobayashi, Hitomi Sezaki, Yusuke Kawamura, Tetsuya Hosaka, Mariko Kobayashi, Satoshi Saitoh, Yoshiyuki Suzuki, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
• Journal: Journal of clinical microbiology (J Clin Microbiol) Vol. 53 Issue 9 Pg. 3039-41 (Sep 2015) ISSN: 1098-660X [Electronic] United States
• PMID: 26135874 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Chemical References

• Antiviral Agents
• RNA, Viral
• Viral Core Proteins
• nucleocapsid protein, Hepatitis C virus

Topics

• Aged
• Amino Acid Substitution
• Antiviral Agents (therapeutic use)
• Carcinoma, Hepatocellular (epidemiology)
• Female
• Genotype
• Hepacivirus (genetics)
• Hepatitis C, Chronic (complications, drug therapy, virology)
• Humans
• Liver Neoplasms (epidemiology)
• Male
• Middle Aged
• Mutation, Missense
• RNA, Viral (blood)
• Retrospective Studies
• Viral Core Proteins (genetics)