Abstract | PURPOSE: METHODS: From January 2000 to December 2013, 1490 PD were performed for periampullary disease. Data from all patients with histologically proven cholangiocarcinoma were reviewed. Preoperative data, post-operative complications, pathologic features, and survival were investigated. RESULTS: Among 50 histologically proven DBDC (3.3 %), 4 patients who underwent CBD resection were excluded. Thus, the study population consisted of 46 patients. Overall surgical morbidity rate was 67.4 %; mortality was nil. Major complications were pancreatic fistula (47.8 %), abdominal collections (34.8 %), post- pancreatectomy hemorrhage (21.7 %), and delayed gastric emptying (10.9 %). The majority of resections were R0 (73.9 %). The presence of metastatic lymph nodes (N1) was identified in 76.1 % of cases. Among N1 cases, the most frequently involved lymph nodes were pancreaticoduodenal nodes (50 %), hepatoduodenal ligament nodes (21.7 %), superior mesenteric artery nodes (8.7 %), and anterior hepatic artery nodes (4.3 %). Overall, survival rates were 88.8, 40, and 18 % at 1, 3, and 5 years, respectively. Median survival was 31 months. By univariate analysis, only tumor grading and nodal metastasis were predictors of poor prognosis (p < 0.05). These findings were not confirmed in multivariate analysis. CONCLUSIONS: This study shows that DBDC is a rare entity even if large surgical series are reviewed. Tumor differentiation and nodal status have been confirmed as important prognostic factors. Pancreaticoduodenectomy remains the procedure of choice in order to obtain free surgical margins and in order to harvest the correct number of lymph nodes for a correct staging.
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Authors | Stefano Andrianello, Salvatore Paiella, Valentina Allegrini, Marco Ramera, Alessandra Pulvirenti, Giuseppe Malleo, Roberto Salvia, Claudio Bassi |
Journal | Langenbeck's archives of surgery
(Langenbecks Arch Surg)
Vol. 400
Issue 5
Pg. 623-8
(Jul 2015)
ISSN: 1435-2451 [Electronic] Germany |
PMID | 26134446
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Bile Duct Neoplasms
(surgery)
- Cholangiocarcinoma
(surgery)
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Pancreaticoduodenectomy
- Postoperative Complications
- Prognosis
- Survival Rate
- Treatment Outcome
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