D-Fagomine attenuates metabolic alterations induced by a high-energy-dense diet in rats.

Abstract

d-Fagomine is a natural iminosugar that counteracts the short-term effects of a high-energy-dense diet on body weight, fasting blood glucose levels and the proportion of gut Enterobacteriales. This suggests that supplementation with d-fagomine for longer periods may delay the onset of other factors related to metabolic syndrome. Here we evaluate the effects of d-fagomine dietary supplementation on relevant metabolic hormones and lipid peroxidation. Adult Sprague-Dawley rats were fed a high-fat high-sucrose diet supplemented or not with d-fagomine (0.065% w/w) for 9 weeks. Weight gain, plasma triglycerides, glucose, insulin, glucagon, ghrelin, leptin, and urine F2-isoprostanes were evaluated. d-Fagomine attenuated the changes induced by the high-energy-dense diet in triglycerides and all the hormones tested. These results suggest that d-fagomine may help to avert the complications associated with unhealthy eating by counteracting the effects of high-energy-dense diets during the early stages of the development of metabolic disorders.

• Authors: Eunice Molinar-Toribio, Jara Pérez-Jiménez, Sara Ramos-Romero, Livia Gómez, Núria Taltavull, Maria Rosa Nogués, Alberto Adeva, Olga Jáuregui, Jesús Joglar, Pere Clapés, Josep Lluís Torres
• Journal: Food & function (Food Funct) Vol. 6 Issue 8 Pg. 2614-9 (Aug 2015) ISSN: 2042-650X [Electronic] England
• PMID: 26130374 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Imino Pyranoses
• Insulin
• Leptin
• Triglycerides
• fagomine

Topics

• Animals
• Blood Glucose (metabolism)
• Body Weight
• Diet, High-Fat (adverse effects)
• Humans
• Imino Pyranoses (administration & dosage)
• Insulin (blood)
• Leptin (blood)
• Male
• Obesity (blood, drug therapy)
• Rats
• Rats, Sprague-Dawley
• Triglycerides (blood)