Oxomollugin, a potential inhibitor of lipopolysaccharide-induced nitric oxide production including nuclear factor kappa B signals.

Abstract

Mollugin, a naphthoquinone derivative, was reported to possess various biological activities such as anti-inflammatory and anti-tumor activity. Mollugin isolated from Rubia tinctorum roots inhibited lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 macrophages. However, mollugin synthesized for further investigation of its anti-inflammatory mechanism showed weak activity in addition to unstable assay results. From the result of analysis on a degradation product of mollugin, oxomollugin was found to be the main active substance of mollugin degradation, showing a potent inhibitory activity on NO-production including nuclear factor kappa B signals.

• Authors: Hiroshi Morita, Hitomi Nishino, Yuki Nakajima, Yoshiaki Kakubari, Asami Nakata, Jun Deguchi, Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda, Yoko Kawasaki, Yukihiro Goda
• Journal: Journal of natural medicines (J Nat Med) Vol. 69 Issue 4 Pg. 608-11 (Oct 2015) ISSN: 1861-0293 [Electronic] Japan
• PMID: 26126771 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Benzopyrans
• Lipopolysaccharides
• NF-kappa B
• Pyrans
• oxomollugin
• Nitric Oxide
• rubimaillin

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology)
• Benzopyrans (chemistry, pharmacology)
• Cell Line
• Lipopolysaccharides (antagonists & inhibitors, pharmacology)
• Macrophages (drug effects, metabolism)
• Mice
• NF-kappa B (metabolism)
• Nitric Oxide (antagonists & inhibitors, biosynthesis, metabolism)
• Pyrans
• Signal Transduction (drug effects)