Peripherally administered serotonin 5-HT3 receptor antagonists reduce inflammatory pain in rats.

Abstract

Intraplantar administration of serotonin 5-HT3 receptor antagonists ICS 205-930 and MDL 72222 (1-100 micrograms; 50 microliters) produced dose-related analgesia against formalin-induced acute- and Freunds adjuvant-induced chronic-inflammatory pain in rats. 5-HT3 receptor antagonists had greater effect in the chronic pain test than in the acute paradigm. In both tests, ICS 205-930 was more potent than MDL 72222. These data further support the involvement of peripheral 5-HT3 sites in inflammatory pain, and suggest the utility of selective 5-HT3 receptor antagonists as peripheral analgesics.

• Authors: J Giordano, L V Rogers
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 170 Issue 1-2 Pg. 83-6 (Oct 24 1989) ISSN: 0014-2999 [Print] Netherlands
• PMID: 2612565 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics
• Anti-Inflammatory Agents, Non-Steroidal
• Indoles
• Serotonin Antagonists
• Tropanes
• Tropisetron
• bemesetron

Topics

• Acute Disease
• Analgesics
• Animals
• Anti-Inflammatory Agents, Non-Steroidal
• Chronic Disease
• Indoles (pharmacology)
• Male
• Nociceptors (drug effects)
• Pain Measurement
• Rats
• Serotonin Antagonists (administration & dosage, pharmacology)
• Tropanes (pharmacology)
• Tropisetron