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111In-Pentetreotide SPECT/CT in Pulmonary Carcinoid.

AbstractAIM:
We evaluated somatostatin receptor scintigraphy (SRS) with (111)In-pentetreotide incremental value in pulmonary carcinoid (PC) diagnosis compared to contrast enhanced Computed Tomography (ceCT).
PATIENTS AND METHODS:
We enrolled 81 patients with ascertained PC, 39 at initial staging and 42 in follow-up; the primary tumor had already been excised in 68 cases. Single Photon emission Computed Tomography (SPECT) images were reconstructed with the iterative method and fused with non-enhanced Computed tomography (CT) images.
RESULTS:
Primary PC or metastatic lesions were ascertained in 55/81 patients and SPECT/CT was positive in 50/55 cases, while ceCT was positive in 44/55. Comparing SPECT/CT with ceCT results, we found a sensitivity of 96 vs. 87.5%, and specificity of 92% vs. 97% for the detection of primary lesion or recurrent disease. A total of 198 lesions were ascertained at SPECT/CT, while 161 at ceCT, with values of sensitivity and specificity of 85.5% and 84.6% for SRS and 75.2% and 90.5% respectively.
CONCLUSION:
(111)In-Pentetreotide SPECT/CT proved to be more sensitive and accurate than ceCT, thus enhancing its role in evaluating patients with PC.
AuthorsAgostino Chiaravalloti, Angela Spanu, Roberta Danieli, Francesca Dore, Bastiana Piras, Antonio Falchi, Mario Tavolozza, Giuseppe Madeddu, Orazio Schillaci
JournalAnticancer research (Anticancer Res) Vol. 35 Issue 7 Pg. 4265-70 (Jul 2015) ISSN: 1791-7530 [Electronic] Greece
PMID26124388 (Publication Type: Journal Article)
CopyrightCopyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
Chemical References
  • Indium Radioisotopes
  • Radiopharmaceuticals
  • Receptors, Somatostatin
  • Somatostatin
  • pentetreotide
Topics
  • Aged
  • Carcinoid Tumor (diagnosis)
  • Female
  • Humans
  • Indium Radioisotopes
  • Lung Neoplasms (diagnosis, metabolism)
  • Male
  • Neuroendocrine Tumors (diagnosis, metabolism)
  • Radiopharmaceuticals
  • Receptors, Somatostatin (metabolism)
  • Sensitivity and Specificity
  • Somatostatin (analogs & derivatives)
  • Tomography, Emission-Computed, Single-Photon (methods)
  • Tomography, X-Ray Computed (methods)

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