THE INFLUENCE AND REGULATORY MECHANISM OF Y-BOX BINDING PROTEIN 1 IN OSTEOSARCOMA AND ITS SIGNIFICANCE.

Abstract

This study quantified the expression of Y-box binding protein 1 (YB-1) by the immunohistochemical method based on pathological paraffin block specimens of aspiration biopsy from patients with osteosarcoma to explore the influence and regulatory mechanism of YB-1 in osteosarcoma and its significance. Patients were divided into two groups with high and low expressed YB-1, and results showed that 7 cases (13.7%) and 18 cases (26.1%) were in level III, and 44 cases (86.3%) and 51 cases (76.9%) were in level IV respectively, and patients with high YB-1 expression quantity had higher malignant tumor degree (p=0.03). Moreover, the tumor necrosis rate induced by chemotherapy in the two groups were 21 cases (41.2%) and 38 cases (51.8%), respectively. By survival analysis, it was found that a 5-year overall survival rate of patients with high YB-1 expression and low YB-1 expression were 61.2% and 76.6%, respectively (p = 0.054), and 5-year event free survival rates were 52.5% and 72.4%, respectively (p = 0.033). Furthermore, metastasis rate of high YB-1 expression and low YB-1 expression were 41.8% and 22.7%, respectively (p = 0.036), indicating that patients with high YB-1 expression had higher pulmonary metastasis rate. Through further study, we discovered that possibly miR-382 plays a regulatory role in YB-1 gene in osteosarcoma.

• Authors: W-P Zhou, X Liu, Y Yang, Y-F Liu
• Journal: Journal of biological regulators and homeostatic agents (J Biol Regul Homeost Agents) 2015 Apr-Jun Vol. 29 Issue 2 Pg. 485-91 ISSN: 0393-974X [Print] Italy
• PMID: 26122241 (Publication Type: Letter)

Chemical References

• MIRN382 microRNA, human
• MicroRNAs
• Neoplasm Proteins
• RNA, Neoplasm
• Y-Box-Binding Protein 1
• YBX1 protein, human

Topics

• Adolescent
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bone Neoplasms (drug therapy, genetics, metabolism, mortality, pathology)
• Cell Line, Tumor
• Cell Movement
• Child
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Lung Neoplasms (secondary)
• Male
• MicroRNAs (physiology)
• Necrosis
• Neoplasm Invasiveness
• Neoplasm Proteins (biosynthesis, genetics, physiology)
• Osteosarcoma (drug therapy, genetics, metabolism, mortality, secondary)
• RNA, Neoplasm (physiology)
• Survival Analysis
• Y-Box-Binding Protein 1 (biosynthesis, genetics, physiology)
• Young Adult