Thirst and sodium appetite in rats with experimental nephrotic syndrome.

Abstract

Nephrotic syndrome is a renal disease accompanied by abnormal body fluid balance. The present experiments investigated the role of behavioral mechanisms in contributing to disordered fluid homeostasis in rats with experimentally-induced nephrotic syndrome. The studies examined water and sodium ingestion under ad libitum conditions and in response to dehydration-related challenges in rats made nephrotic by treatment with the antibiotic, adriamycin. Rats with nephrotic syndrome had greater ad libitum water intakes beginning 3 weeks after treatment, but daily sodium (0.3M NaCl) intakes were not affected. Nephrotic rats showed attenuated water and sodium intakes after combined treatment with furosemide (10mg/kg) and captopril (2mg/kg), reduced water intakes after 20h of water deprivation, and diminished water intakes, plasma renin activity and aldosterone secretion after subcutaneous isoproterenol (30 μg/kg). However, the adriamycin-treated animals had normal water intakes in response to subcutaneous hypertonic saline (4% at 0.75 ml/100g) and central injections of angiotensin II (10, 20, and 50 ng). The results suggest that water and sodium ingestion in response to hypovolemic/hypotensive stimuli are disturbed in nephrotic rats, and provide evidence that the disordered behaviors reflect disturbances of the peripheral renin-angiotensin-aldosterone system.

• Authors: Jie Xu, Alan Kim Johnson, Robert L Thunhorst
• Journal: Physiology & behavior (Physiol Behav) Vol. 149 Pg. 317-23 (Oct 01 2015) ISSN: 1873-507X [Electronic] United States
• PMID: 26120029 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Antibiotics, Antineoplastic
• Bronchodilator Agents
• Diuretics
• Vasoconstrictor Agents
• Angiotensin II
• Furosemide
• Doxorubicin
• Captopril
• Sodium
• Renin
• Isoproterenol

Topics

• Angiotensin II (pharmacology)
• Animals
• Antibiotics, Antineoplastic (pharmacology)
• Appetite (drug effects, physiology)
• Blood Pressure (drug effects)
• Bronchodilator Agents (pharmacology)
• Captopril (pharmacology)
• Disease Models, Animal
• Diuretics (pharmacology)
• Doxorubicin (toxicity)
• Drinking (drug effects)
• Furosemide (pharmacology)
• Isoproterenol (pharmacology)
• Male
• Nephrotic Syndrome (physiopathology)
• Rats
• Rats, Sprague-Dawley
• Renin (blood)
• Sodium (metabolism)
• Thirst (physiology)
• Vasoconstrictor Agents (pharmacology)