Enhanced net mass transfer of HDL cholesteryl esters to Apo B-containing lipoproteins in patients with peripheral vascular disease.

Abstract

In vitro net mass transfer of HDL cholesteryl ester to apolipoprotein (Apo) B-containing lipoproteins (HDL-CET) was found to be nearly twofold higher in plasma from 35 male patients with peripheral vascular disease compared to the values of 27 age- and sex-matched healthy controls (P less than 0.001). Differences in HDL-CET were predominantly observed between normolipidemic patients and controls, and were also demonstrable in pairs of patients and controls with similar HDL cholesterol, VLDL + LDL cholesterol, and triglyceride concentrations. Within the control group, higher HDL-CET was found in individuals with enhanced triglyceride or VLDL + LDL cholesterol levels. This dependence was not observed in the patient group. Consequently, enhanced HDL-CET in the patients seems to be independent of plasma lipid levels.

• Authors: K Rühling, R Zabel-Langhennig, U Till, K Thielmann
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 184 Issue 3 Pg. 289-96 (Oct 16 1989) ISSN: 0009-8981 [Print] Netherlands
• PMID: 2612001 (Publication Type: Journal Article)

Chemical References

• Apolipoproteins
• Apolipoproteins B
• Cholesterol Esters
• Cholesterol, HDL
• Cholesterol, LDL
• Cholesterol, VLDL
• HDL cholesteryl ester
• Lipoproteins, HDL
• Triglycerides

Topics

• Aged
• Apolipoproteins (blood)
• Apolipoproteins B (blood)
• Cholesterol Esters (blood)
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Cholesterol, VLDL (blood)
• Humans
• Lipoproteins, HDL (blood)
• Male
• Middle Aged
• Reference Values
• Triglycerides (blood)
• Vascular Diseases (blood)