NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus.

Abstract

NAD(+) has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded protein response. This improved understanding of NAD(+) metabolism revived interest in NAD(+)-boosting strategies to manage a wide spectrum of diseases, ranging from diabetes to cancer. In this review, we summarize how NAD(+) metabolism links energy status with adaptive cellular and organismal responses and how this knowledge can be therapeutically exploited.

• Authors: Carles Cantó, Keir J Menzies, Johan Auwerx
• Journal: Cell metabolism (Cell Metab) Vol. 22 Issue 1 Pg. 31-53 (Jul 07 2015) ISSN: 1932-7420 [Electronic] United States
• PMID: 26118927 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• NAD
• Poly(ADP-ribose) Polymerases
• Sirtuins

Topics

• Aging
• Animals
• Cell Nucleus (metabolism)
• Energy Metabolism
• Homeostasis
• Humans
• Metabolic Diseases (metabolism)
• Mitochondria (metabolism)
• Molecular Targeted Therapy
• NAD (metabolism)
• Neoplasms (metabolism)
• Neurodegenerative Diseases (metabolism)
• Poly(ADP-ribose) Polymerases (metabolism)
• Sirtuins (metabolism)