Abstract |
NAD(+) has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded protein response. This improved understanding of NAD(+) metabolism revived interest in NAD(+)-boosting strategies to manage a wide spectrum of diseases, ranging from diabetes to cancer. In this review, we summarize how NAD(+) metabolism links energy status with adaptive cellular and organismal responses and how this knowledge can be therapeutically exploited.
|
Authors | Carles Cantó, Keir J Menzies, Johan Auwerx |
Journal | Cell metabolism
(Cell Metab)
Vol. 22
Issue 1
Pg. 31-53
(Jul 07 2015)
ISSN: 1932-7420 [Electronic] United States |
PMID | 26118927
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
|
Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
- NAD
- Poly(ADP-ribose) Polymerases
- Sirtuins
|
Topics |
- Aging
- Animals
- Cell Nucleus
(metabolism)
- Energy Metabolism
- Homeostasis
- Humans
- Metabolic Diseases
(metabolism)
- Mitochondria
(metabolism)
- Molecular Targeted Therapy
- NAD
(metabolism)
- Neoplasms
(metabolism)
- Neurodegenerative Diseases
(metabolism)
- Poly(ADP-ribose) Polymerases
(metabolism)
- Sirtuins
(metabolism)
|