Abstract | STUDY OBJECTIVES: DESIGN: Cross-sectional survey. SETTINGS: Four French national reference centers for narcolepsy. PATIENTS: One hundred eight consecutively referred children aged younger than 18 y with narcolepsy, with (NwC, n = 86) or without cataplexy (NwoC, n = 22), and 67 healthy controls. INTERVENTIONS: The participants, their families, and sleep specialists completed a structured interview and questionnaires about sleep, daytime sleepiness, fatigue, and ADHD symptoms ( ADHD-rating scale based upon Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision [DSM-IV-TR] symptoms), and use of psychostimulants for the treatment of narcolepsy (administered in 68.2%). Polysomnographic measures were collected. MEASUREMENTS AND RESULTS: Clinically significant levels of ADHD symptoms were found in 4.8% of controls compared with 35.3% in patients with NwoC (P < 0.001) and 19.7% in patients with NwC (P < 0.01). Total ADHD scores were 6.4 (95% confidence interval [CI]: 4.5, 9.0) in controls compared with 14.2 (95% CI: 10.6, 18.9; P < 0.001), in patients with NwoC and 12.2 (95% CI: 9.8, 15.3; P < 0.01) in patients with NwC; subscores of inattention and hyperactivity/impulsivity were also significantly higher in both narcolepsy groups compared with controls. No difference was found between the NwC and NwoC groups for any ADHD measure. ADHD symptom severity was associated with increased levels of sleepiness, fatigue, and insomnia. Compared with the 34 untreated patients, the 73 patients treated with psychostimulants ( modafinil in 91%) showed a trend toward lower narcolepsy symptoms but not lower ADHD symptoms. CONCLUSIONS:
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Authors | Michel Lecendreux, Sophie Lavault, Régis Lopez, Clara Odilia Inocente, Eric Konofal, Samuele Cortese, Patricia Franco, Isabelle Arnulf, Yves Dauvilliers |
Journal | Sleep
(Sleep)
Vol. 38
Issue 8
Pg. 1285-95
(Aug 01 2015)
ISSN: 1550-9109 [Electronic] United States |
PMID | 26118560
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 Associated Professional Sleep Societies, LLC. |
Chemical References |
- Benzhydryl Compounds
- Central Nervous System Stimulants
- Modafinil
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Topics |
- Adolescent
- Attention Deficit Disorder with Hyperactivity
(complications, psychology)
- Benzhydryl Compounds
(therapeutic use)
- Case-Control Studies
- Cataplexy
(complications, drug therapy, physiopathology, psychology)
- Central Nervous System Stimulants
(therapeutic use)
- Child
- Child, Preschool
- Cross-Sectional Studies
- Diagnostic and Statistical Manual of Mental Disorders
- Fatigue
(complications)
- Female
- France
- Humans
- Interviews as Topic
- Male
- Modafinil
- Narcolepsy
(complications, drug therapy, physiopathology, psychology)
- Sleep Initiation and Maintenance Disorders
(complications)
- Sleep Stages
- Surveys and Questionnaires
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