Oxypurinol attenuates ischemia-induced hippocampal damage in the gerbil.

Abstract

Oxypurinol, an inhibitor of the enzyme xanthine oxidase, reduced ischemic hippocampal damage and the associated hypermotility in Mongolian gerbils. Cerebral ischemia was induced in unanesthetized gerbils by a bilateral 5-min occlusion of the carotid arteries. Oxypurinol (40 mg/kg, IP), administered 20 min prior to carotid occlusion, prevented the increase in locomotor activity observed in saline-injected ischemic animals and significantly reduced the damage to, and loss of, CA1 hippocampal neurons observed 5 days postischemia. These findings suggest that oxypurinol may be useful for the prevention of cerebral ischemic damage.

• Authors: J W Phillis
• Journal: Brain research bulletin (Brain Res Bull) Vol. 23 Issue 6 Pg. 467-70 (Dec 1989) ISSN: 0361-9230 [Print] United States
• PMID: 2611688 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Enzyme Inhibitors
• Pyrimidines
• Xanthine Oxidase
• Oxypurinol

Topics

• Animals
• Enzyme Inhibitors (therapeutic use)
• Gerbillinae
• Hippocampus (pathology, physiopathology)
• Ischemic Attack, Transient (drug therapy, enzymology, pathology)
• Male
• Oxypurinol (therapeutic use)
• Pyrimidines (therapeutic use)
• Xanthine Oxidase (metabolism)