Abstract |
We report a rare multiple sclerosis (MS) patient who developed malignant cerebral edema related to progressive multifocal encephalopathy (PML) immune reconstitution inflammatory syndrome (IRIS) after natalizumab discontinuation. The patient subsequently required a decompressive hemicraniectomy to reduce intracranial pressure and to avoid uncal herniation. PML is a demyelinating disease of the central nervous system (CNS) which affects oligodendrocytes and is caused by reactivation of latent John Cunningham virus. Natalizumab is a known risk factor (1 in 1000) for MS patients treated with this drug. Discontinuation of natalizumab treatment decreases the risk of PML progression, but a massive inflammatory response can occur after cell-mediated immune surveillance is reestablished in the CNS, causing immune reconstitution inflammatory syndrome (IRIS). Treatment of IRIS usually consists of steroids and plasma exchange to lessen the immune response, however, mortality has been reported at up to 29.4%, despite aggressive medical treatment. We discuss our management strategy with a review of the pertinent literature.
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Authors | Lee A Tan, Demetrius K Lopes |
Journal | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
(J Clin Neurosci)
Vol. 22
Issue 10
Pg. 1669-71
(Oct 2015)
ISSN: 1532-2653 [Electronic] Scotland |
PMID | 26115897
(Publication Type: Case Reports, Journal Article, Review)
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Copyright | Copyright © 2015 Elsevier Ltd. All rights reserved. |
Chemical References |
- Antibodies, Monoclonal, Humanized
- Natalizumab
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Topics |
- Adult
- Antibodies, Monoclonal, Humanized
(adverse effects)
- Brain Edema
(diagnosis, etiology, surgery)
- Disease Management
- Female
- Humans
- Immune Reconstitution Inflammatory Syndrome
(chemically induced, complications, diagnosis)
- Leukoencephalopathy, Progressive Multifocal
(chemically induced, complications, diagnosis)
- Multiple Sclerosis
(diagnosis, drug therapy)
- Natalizumab
(adverse effects)
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