β-Amyloid binding in elderly subjects with declining or stable episodic memory function measured with PET and [¹¹C]AZD2184.

Abstract

PURPOSE:

Cognitive decline has been suggested as an early marker for later onset of Alzheimer's disease. We therefore explored the relationship between decline in episodic memory and β-amyloid using positron emission tomography (PET) and [(11)C]AZD2184, a radioligand with potential to detect low levels of amyloid deposits.

METHODS:

Healthy elderly subjects with declining (n = 10) or stable (n = 10) episodic memory over 15 years were recruited from the population-based Betula study and examined with PET. Brain radioactivity was measured after intravenous administration of [(11)C]AZD2184. The binding potential BP ND was calculated using linear graphical analysis with the cerebellum as reference region.

RESULTS:

The binding of [(11)C]AZD2184 in total grey matter was generally low in the declining group, whereas some binding could be observed in the stable group. Mean BP ND was significantly higher in the stable group compared to the declining group (p = 0.019). An observation was that the three subjects with the highest BP ND were ApoE ε4 allele carriers.

CONCLUSIONS:

We conclude that cognitive decline in the general population does not seem to stand by itself as an early predictor for amyloid deposits.

• Authors: Patrik Mattsson, Anton Forsberg, Jonas Persson, Lars Nyberg, Lars-Göran Nilsson, Christer Halldin, Lars Farde
• Journal: European journal of nuclear medicine and molecular imaging (Eur J Nucl Med Mol Imaging) Vol. 42 Issue 10 Pg. 1507-11 (Sep 2015) ISSN: 1619-7089 [Electronic] Germany
• PMID: 26115835 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 2-(6-(methylamino)pyridin-3-yl)-1,3-benzothiazol-6-ol
• Aminopyridines
• Amyloid beta-Peptides
• Benzothiazoles
• Carbon Radioisotopes
• Radiopharmaceuticals

Topics

• Aged
• Aminopyridines (pharmacokinetics)
• Amyloid beta-Peptides (metabolism)
• Benzothiazoles (pharmacokinetics)
• Carbon Radioisotopes (pharmacokinetics)
• Cognition Disorders (diagnostic imaging, metabolism)
• Female
• Humans
• Male
• Memory Disorders (diagnostic imaging, metabolism)
• Memory, Episodic
• Middle Aged
• Molecular Imaging (methods)
• Positron-Emission Tomography (methods)
• Protein Binding
• Radiopharmaceuticals (pharmacokinetics)
• Reproducibility of Results
• Sensitivity and Specificity