Links between environmental chemicals and human health have emerged over the last few decades, but the effects from polyaromatic
hydrocarbons were less studied, compared to other commonly known environmental chemicals such as
heavy metals, phthalates,
arsenic,
phenols and pesticides. Therefore, it was aimed to study the relationships of urinary polyaromatic
hydrocarbons and adult
cardiovascular disease and
cancer using human sample in a national and population-based study in recent years. Data was retrieved from US National Health and Nutrition Examination Surveys, 2011-2012, including demographics, self-reported health conditions and urinary polyaromatic
hydrocarbons. Statistical analyses included chi-square test, t test, survey-weighted logistic regression modeling and population attributable risk (PAR) estimation. Of 5560 American adults aged 20-80 and included in the statistical analysis, urinary polyaromatic
hydrocarbons (representatively in one-third sample) were observed to be higher in people with
cardiovascular disease and total
cancer. In particular, urinary
4-hydroxyphenanthrene was associated with
hypertension (odds ratio (OR) 1.33, 95% confidence interval (CI) 1.00-1.76, P = 0.048, PAR 5.1%), urinary
1-hydroxypyrene was significantly associated with
heart attack (OR 1.47, 95%CI 1.05-2.06, P = 0.027, PAR 1.7%), and urinary 2-hydroxynapthalene (2-naphthol) was associated with
cancer (OR 1.46, 95%CI 1.12-1.90, P = 0.008, PAR 3.9%). Urinary polyaromatic
hydrocarbons were associated with adult
hypertension,
heart attack and
cancer, although the causality cannot be established. From the research perspective, future studies with a longitudinal or experimental approach would be suggested. From the law and public health perspectives, regulation on minimizing exposure to polyaromatic
hydrocarbons might need to be considered in future health and environmental policies and intervention programs.