Abstract | INTRODUCTION: OBJECTIVE: To investigate the impact of vitamin D in a transgenic rat model of angiotensin II-mediated hypertensive organ failure. METHODS: RESULTS: The vitamin D depleted group had higher blood pressure at week 1 (mean difference 23.4mmHg, 95% CI 9.1-37.7) and tended to have higher blood pressure in weeks 2 and 3 (mean difference 14.3mmHg 95% CI -0.02-28.7 and 15.2mmHg 95% CI -1.5-33). The depletion group had higher heart-to- body weight ratio, and a trend towards higher ANP and BNP levels. The group receiving paricalcitol did not perform better. No differences were found between groups in mortality or proteinuria. CONCLUSION:
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Authors | Louise Bjørkholt Andersen, Florian Herse, Henrik Thybo Christesen, Ralf Dechend, Dominik Müller |
Journal | Pregnancy hypertension
(Pregnancy Hypertens)
Vol. 3
Issue 2
Pg. 69
(Apr 2013)
ISSN: 2210-7789 [Print] Netherlands |
PMID | 26105863
(Publication Type: Journal Article)
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Copyright | Copyright © 2013. Published by Elsevier B.V. |