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PP005. Vitamin D depletion aggravates hypertension in transgenic rats.

AbstractINTRODUCTION:
Vitamin D may ameliorate hypertension and kidney disease through genomic and extra-genomic pathways.
OBJECTIVE:
To investigate the impact of vitamin D in a transgenic rat model of angiotensin II-mediated hypertensive organ failure.
METHODS:
In 4-week-old age-matched rats overexpressing the human renin and angiotensinogen genes, group 1 (n=18) received vitamin D depleted chow; group 2 (n=15) standard chow and intraperitoneal paricalcitol at 800ng/kg thrice weekly; and group 3 (n=15) standard chow and vehicle injections. Blood pressure (tail cuff) and 24-h albuminuria were determined once weekly. After three weeks, animals were sacrificed. Heart tissue was examined for atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) by RT-PCR.
RESULTS:
The vitamin D depleted group had higher blood pressure at week 1 (mean difference 23.4mmHg, 95% CI 9.1-37.7) and tended to have higher blood pressure in weeks 2 and 3 (mean difference 14.3mmHg 95% CI -0.02-28.7 and 15.2mmHg 95% CI -1.5-33). The depletion group had higher heart-to-body weight ratio, and a trend towards higher ANP and BNP levels. The group receiving paricalcitol did not perform better. No differences were found between groups in mortality or proteinuria.
CONCLUSION:
Short-term vitamin D depletion aggravated hypertension and end-organ damage in a rat model of angiotensin II-induced hypertension. Short-term interventions with high-dose vitamin D analogues had no protective effect.
AuthorsLouise Bjørkholt Andersen, Florian Herse, Henrik Thybo Christesen, Ralf Dechend, Dominik Müller
JournalPregnancy hypertension (Pregnancy Hypertens) Vol. 3 Issue 2 Pg. 69 (Apr 2013) ISSN: 2210-7789 [Print] Netherlands
PMID26105863 (Publication Type: Journal Article)
CopyrightCopyright © 2013. Published by Elsevier B.V.

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