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The times they are a-changin': carbapenems for extended-spectrum-β-lactamase-producing bacteria.

Abstract
Several antimicrobial agents are being investigated as alternatives to carbapenems in the treatment of infections caused by ESBL-producing Enterobacteriaceae, which may be useful in avoiding overuse of carbapenems in the context of recent global spread of carbapenem-resistant Enterobacteriaceae. The most promising candidates for invasive infections so far are β-lactam/β-lactamase inhibitor combinations and cephamycins.
AuthorsJesús Rodríguez-Baño
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 59 Issue 9 Pg. 5095-6 (Sep 2015) ISSN: 1098-6596 [Electronic] United States
PMID26100709 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015, American Society for Microbiology. All Rights Reserved.
Chemical References
  • Anti-Bacterial Agents
  • Carbapenems
  • Cephamycins
  • beta-Lactamase Inhibitors
  • beta-Lactamases
Topics
  • Anti-Bacterial Agents (pharmacology)
  • Carbapenems (pharmacology)
  • Cephamycins (pharmacology)
  • Enterobacteriaceae (drug effects, enzymology)
  • Microbial Sensitivity Tests
  • beta-Lactamase Inhibitors (pharmacology)
  • beta-Lactamases (metabolism)

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