Uterine artery embolization by use of porous gelatin particles for symptomatic uterine leiomyomas: comparison with hand-cut gelatin sponge particles.

Abstract

PURPOSE:

To evaluate the results of uterine artery embolization (UAE) for symptomatic uterine leiomyoma by use of porous gelatin particles (PGP) in comparison with conventional hand-cut gelatin sponge particles.

MATERIALS AND METHODS:

One hundred and fifteen consecutive patients who had undergone UAE were retrospectively assessed. The first 64 patients were treated with hand-cut gelatin sponge and the last 51 with PGP. Extent of infarction, volume reduction of the dominant leiomyoma on magnetic resonance (MR) imaging, and change in symptoms were assessed.

RESULTS:

UAE was successfully performed for all patients. No major complications were observed. MR images one month after UAE showed that the mean extent of infarction of the dominant leiomyoma was 97 % for patients treated with PGP and 96 % for those treated with hand-cut gelatin sponge. Volume reductions of the dominant leiomyoma after 3, 6, 12, and 24 months were, respectively, 45, 56, 62, and 66 % for use of PGP and 45, 57, 63, and 68 % for use of hand-cut gelatin sponge. Symptoms including heavy menstrual bleeding, heavy menstrual pain, and abdominal heaviness had improved by 95-100 % at 12 months. There was no difference between the two groups.

CONCLUSION:

UAE with PGP is safe, and as effective as conventional gelatin sponge particles.

• Authors: Yuichiro Izumi, Shuji Ikeda, Akira Kitagawa, Eisuke Katsuda, Makiyo Hagihara, Seiji Kamei, Toyohiro Ota, Tsuneo Ishiguchi
• Journal: Japanese journal of radiology (Jpn J Radiol) Vol. 33 Issue 8 Pg. 461-70 (Aug 2015) ISSN: 1867-108X [Electronic] Japan
• PMID: 26100298 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Hemostatics
• Gelatin

Topics

• Adult
• Female
• Follow-Up Studies
• Gelatin (therapeutic use)
• Gelatin Sponge, Absorbable (therapeutic use)
• Hemostatics (therapeutic use)
• Humans
• Leiomyoma (diagnosis, surgery)
• Magnetic Resonance Imaging
• Middle Aged
• Retrospective Studies
• Treatment Outcome
• Uterine Artery Embolization (methods)
• Uterine Neoplasms (diagnosis, surgery)