Abstract | BACKGROUND AND PURPOSE: METHODS: All the subjects were evaluated for the presence and severity of ICAS and ECAS through computerized tomographic angiography (CTA) covered the whole brain down to the level of aortic arch. Lp-PLA2 mass was measured by enzyme linked immunoassay. The association of Lp-PLA2 and vascular stenosis was analyzed through multivariate logistic regression. RESULTS: Among 414 participants, 163 (39.4%) had no ICAS or ECAS, 63 (15.2%) had ECAS only, 111 (26.8%) had ICAS only and 77 (18.6%) had concurrent extraintracranial stenosis. Lp-PLA2 mass was significantly associated with isolated ICAS (OR: 2.3; 95% CI: 1.14-4.64), and concurrent stenosis (OR: 3.93; 95% CI: 1.62-9.51), but was not related to isolated ECAS (OR: 1.54; 95% CI: 0.68-3.48). Lp-PLA2 mass was also associated with moderate to severe ICAS no matter how was the ECAS. Moreover, patients with higher Lp-PLA2 mass showed more sever ICAS and had more intracranial arterial lesions. CONCLUSION: This study revealed the association of Lp-PLA2 mass with ICAS in stroke-free hypertensive patients in Chinese population. The further long-term cohort study was warranted to elucidate the concrete effect of Lp-PLA2 on the asymptomatic ICAS.
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Authors | Yan Wang, Jin Zhang, Yuesheng Qian, Xiaofeng Tang, Huawei Ling, Kemin Chen, Pingjin Gao, Dingliang Zhu |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 6
Pg. e0130473
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 26098634
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- 1-Alkyl-2-acetylglycerophosphocholine Esterase
|
Topics |
- 1-Alkyl-2-acetylglycerophosphocholine Esterase
(blood)
- Aged
- Biomarkers
(blood)
- Constriction, Pathologic
(blood, complications, diagnostic imaging)
- Female
- Humans
- Hypertension
(blood, complications, diagnostic imaging)
- Intracranial Arterial Diseases
(blood, complications, diagnostic imaging)
- Male
- Middle Aged
- Radiography
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